Treatment Resistant Depression

Major Depressive Disorder is one of the most acute, widespread pathologies of the 21st century, affecting nearly 15 million American adults annually(1).

Patients suffering from Major Depressive Disorder are traditionally treated with antidepressants. However, too often, traditional antidepressants fail to bring the hoped-for relief to patients(2), and frequently cause adverse side effects(3).

Have Antidepressants Failed to Work for You

Antidepressants fail to provide an adequate solution for many patients, and often entail harsh side effects(3), from nausea, insomnia and anxiety to weight gain and sexual dysfunction, leading many patients to stop taking their medication or give up on feeling better.

Talk therapy is also ineffective for many, requires many hours spent with a therapist, and has a high cost.

Another alternative, electro-convulsive therapy (ECT), requires anesthesia within a hospital setting, and is associated with memory loss(9).

As a result, many patients with depression feel trapped in their condition with limited solutions.

We offer patients a free, state of the the art evaluation of their depression, and an opportunity to participate in clinical trials, where they gain access to promising new treatments for depression. These newer treatments currently in development can work quicker than traditional antidepressants, and without uncomfortable side effects. They do not require anesthesia or hospitalization, but can be given safely and conveniently in our office. If you or your loved one are suffering from depression, contact our office to set up a free consultation.

To learn more about our current clinical trial on depression.

1. Kessler RC, Chiu WT, Demler O, Walters EE. Prevalence, severity, and comorbidity of twelve-month DSM-IV disorders in the National Comorbidity Survey Replication (NCS-R). Archives of General Psychiatry 2005;62(6):617-627.

2. Rush AJ, Trivedi MH, Wisniewski SR, Nierenberg AA, Stewart JW, Warden D, et al. Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: A STAR*D report. Am J Psychiatry 2006;163(11):1905–1917.

3. Fabbri C, Marsano A, Balestri M, De Ronchi D, Serretti A. Clinical features and drug induced side effects in early versus late antidepressant responders. J Psychiatr Res 2013;47(10):1309-1318.

4. FDA 510(k) No. K122288.

5. Levkovitz Y. et al. Efficacy and safety of deep transcranial magnetic stimulation for major depression: a prospective, multi-center, randomized, controlled trial. World Psychiatry 2015; Vol.14, 64-73.

6. Levkovitz Y, Harel EV, Roth Y, Braw Y, Sheer A Katz L, GersnerR and Zangen A. (2009) Deep transcranial magnetic stimulation of the prefrontal cortex – Effectiveness in major depression. Brain Stimulation 2: 188-200.

7. Isserles M, Rosenberg O, Dannon P, Lerer B and Zangen A (2011) Cognitive emotional reactivation during deep transcranial magnetic stimulation over the prefrontal cortex of depressive patients affects antidepressant outcomes. Journal of Affective Disorders 128: 235-242.

8. Harel EV, Rabany L, Deutsch L, Bloch Y, Zangen A, LevkovitzY. H-coil repetitive transcranial magnetic stimulation for treatment resistant major depressive disorder: An 18-week continuation safety and feasibility study. World J Biol Psychiatry 2014;15(4):298-306.

9. Lawrence Park, AM, MD. (2011). Risks and Side Effects of ECT. Psych Central. Retrieved on December 3, 2014, from

Leave a reply